Álvaro Gutiérrez-Uzquiza

During the past 14 years I have focused on developing effective therapies for the treatment of cancer and other diseases. During my PhD and postdoctoral period at University of Pennsylvania, I focused on the study of the the molecular mechanisms governing the development, progression and metastatic processes of prostate cancer as well as other diseases.

In 2016, I was hired as Research Scientist at the Translational Lab at Center for Applied Genomics at the Children’s Hospital of Philadelphia to design and develop mammalian cellular/murine models to expand the results of genetics analyses with functional biological data and functional testing of new drugs. My findings during that time have opened new therapeutics opportunities and have been already published (Li, et al, HMG 2018; Li et al, Nature Medicine 2019; Gutierrez-Uzquiza et al. Nat Comm (under review)). In 2018 I came back to Spain to develop my own research supported by the competitive program “Atraccion de talent 2017”. I am combining my expertise in cancer and metastasis together with the CRISPR/Cas9 technology and development of mammalian model to uncover the molecular mechanism of metastasis and other diseases. My research focuses on two main areas:

Functional discoveries in the area of metastasis: Focusing on the understanding of the cellular and molecular factors implicated in metastasis to identify novel and effective therapeutic targets to decelerate or arrest the emergence and progression of metastatic tumors. To this end I am developing a screening based on CRISPR/Cas9 libraries to unbiasedly identify metastasis-associated genes in prostate cancer

Development of mammalian cellular models for validation and characterization of genetic disorders and drug discovery: As a second interest I am using state-of-the-art technologies including CRISPR/Cas9, flow cytometry and advanced cell culture techniques approaches perform experiments to functionally validate the mutations identified by the genetic analysts.

0